Overweight treatment is a problem of modern medicine. Overweight is now observed in a huge number of people, therefore obesity is considered to be a common problem. Overweight is observed due to improper feeding, however, even insignificant change in metabolism or in an organism state may lead to disorders and cause overweight. However more often obesity is caused by overeating and junk food and is supposed to be treated from inside.

Adipex and Phentermine are the most popular, demanded and effective medications for overweight treatment. These medications are widely used in obesity treatment and are characterized by a very strong action. Both Adipex and Phentermine have been approved by FDA to usage and distribution. Practically these two medications are used worldwide and results of use are very positive.

Due to efficiency and safety combination, Adipex and Phentermine have earned a great reputation and annually one million prescriptions are indicated for both medications. Adipex is Phentermine used as a fast drug.

Thousands of people suffer from obesity these days. Many of them are dreaming to change their image and lose all those kilograms, accumulated over the years. Sometimes, to lose weight you need just to stick to healthy eating and systemic physical activity.

In addition to traditional weight loss methods (diets, physical exercises), modern medicine offers various anorexigenic drugs that can become a good supplement to a complex weight loss program.

Adipex Retard is one of the anti-obesity drugs. This medication is included into the pharmaceutical group, called anorectic drugs. Anatomical Therapeutic Chemical (ATC) classification of Adipex Retard anorectic drug: A08AA01.

Adipex Retard anti-obesity drug contains active ingredient – Phentermine resinate. International nonproprietary name of this active ingredient – Phentermine. Phentermine belongs to sympathomimetic amines pharmacological group, providing anorexigenic activity. Anorectic effect of Phentermine occurs in 2.5 hours after drug intake and lasts for 8 hours.

Adipex Retard anorectic drug is produced in soft gelatin capsules, ensuring a controlled release of Phentermine active substance. Each capsule contains 75 mg of Phentermine resinate. This equals to 15 mg of Phentermine active substance and 65 mg of excipients.

The excipients are usually the same: hydrogenated soybean oil, soy lecithin, 70% Sorbitol, sodium propylparaben food additive, sodium methylparaben preservative, castor oil, orange yellow food coloring and sorbitol.

In 2.5 hours after the intake of Adipex Retard anorexigenic drug, the capsule components are quickly absorbed from the gastrointestinal tract into the blood.

The maximum concentration of Phentermine in the body is reached in the next 4-6 hours. The half-life period of Adipex Retard is 20-25 hours. The drug is excreted mostly by kidneys. Phentermine is metabolized easily and has no active metabolite.

The drug is indicated in such types of obesity, as:

  • alimentary obesity with the body mass index (BMI) 30 and above;
  • alimentary obesity with BMI 27 and above, accompanied with other risk factors, caused by excessive body mass (e.g. violated lipid metabolism or insulin dependent diabetes or type 2 diabetes mellitus).

Routes of administration and doses

Adipex Retard anti-obesity caps are intended for adults and teenagers over 12 years old for obesity treatment. For elderly people and teens under 12 years old, this anorectic drug is contraindicated.

It is recommended to carry out the therapy by means of Adipex Retard anorectic drug under the supervision of a doctor, experienced in obesity treatment. Before the treatment begins, the doctor must exclude secondary organic causes of obesity (endocrine and hypothalamic disorders).

The anti-obesity treatment by means of Adipex Retard drug must be carried out as a complex therapy along with adequate physical loads and low-calorie diets. Do not take Adipex Retard in the evening as this psychostimulant can cause insomnia and nervousness.

A regular dose of the drug is one capsule, taken once daily. Please take only 1 capsule in the morning, not chewing, with a full glass of water. In rare cases, the dose can be increased up to 2 capsules a day.

The duration of treatment by means of Adipex Retard weight loss capsules depends on its effectiveness and the achieved result. A regular treatment course lasts for 4-6 weeks but must not exceed three months.

The following disorders and risk factors are Adipex Retard contraindications:

  • glaucoma
  • hypothyroidism
  • allergy to soy products
  • pheochromocytoma
  • renal insufficiency
  • cerebrovascular disease
  • psychiatric diseases
  • prostate adenoma
  • pulmonary hypertension
  • cardiovascular diseases
  • hypersensitivity to the active substance or one of the excipients

Special precautions for Adipex Retard use

During a long-term use of Adipex Retard, patients may develop pharmacological tolerance to Phentermine active substance.

Rarely, but still possible the cases of negative effect of Adipex Retard on the cardiovascular system. The reason for this effect is a sudden weight loss of a patient during anti-obesity treatment.

Special attention should be pain to the patients, suffering from epilepsy. Adipex Retard contains sorbitol. Therefore, this drug is not recommended for patients, allergic to sugar substitutes.

Phentermine is contraindicated to women in early pregnancy. After the first trimester, in rare cases, women can use Phentermine under the supervision of a skilled doctor and obstetrician-gynecologist only. Phentermine is contraindicated in breastfeeding.

Adipex Retard drug interactions

In a concomitant use of Adipex Retard slimming caps with other psychotropic drugs (Thorazine, Haloperidol) the efficiency of anti-obesity therapy is reduced. In addition, the reduced therapeutic effect of Phentermine is often caused by Tricyclic and tetracyclic antidepressants.

The combination of Adipex Retard and MAO inhibitors (e.g. Parnate, Marplan) may cause hypertensive crisis. Alcohol and caffeine increase the effect of Phentermine on the central nervous system. The concomitant use of Adipex Retard weight loss capsules and inhalational agents, administered into the respiratory tract of a patient (e.g. chloroform, Fluothane) can cause cardiac arrhythmia.

Side effects

Most often, side effects of Adipex Retard anti-obesity caps occur in the beginning of the treatment (the first 4 weeks) and do not cause patients much discomfort.

Side effects from the central nervous system are manifested in the form of psychosis, depression, overexcitation, insomnia, headache and dizziness. Side effects from the cardiovascular system are manifested as tachycardia, precordial pain, arrhythmia and hypertension.

Such Adipex Retard side effects as nausea, diarrhea or constipation are typical gastrointestinal adverse reactions arising during the therapy using this weight loss drug.

It should be noted that increased dose of Phentermine may worsen the side effects. In case of overdose, a patient might have one or several symptoms:

  • seizure
  • sleepiness
  • severe anxiety
  • tremor of extremities and entire body
  • increased segmental reflexes
  • visual and auditory hallucinations
  • rapid shallow breathing (over 20 per minute)

The drug overdose requires a symptomatic treatment as there is no special antidote for it. A detox therapy method in case of Phentermine overdose is a forced diuresis or the use of a sedative drug, as well as gastric lavage.

The expiration date is 5 years. The drug should be stored in the original package at the temperature below 25°C, in a dark and dry place. The packaging: blister containing 30 or 100 capsules.

The anti-obesity treatment requires a serious approach and insistence. The properly chosen method to fight against extra weight depends on age and physical or mental state of the body. Adipex Retard capsules are effective almost for everybody who wants to lose the body weight. Adipex Retard anorexigenic drug makes the treatment process easy and effective.

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